Kiyohiko sugano biopharmaceutics modeling and simulations theory practice methods and applications

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Kiyohiko Sugano Biopharmaceutics Modeling and Simulations. Theory, Practice, Methods, and Applications

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31232057

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A comprehensive introduction to using modeling and simulation programs in drug discovery and development Biopharmaceutical modeling has become integral to the design and development of new drugs. Influencing key aspects of the development process, including drug substance design, formulation design, and toxicological exposure assessment, biopharmaceutical modeling is now seen as the linchpin to a drug's future success. And while there are a number of commercially available software programs for drug modeling, there has not been a single resource guiding pharmaceutical professionals to the actual tools and practices needed to design and test safe drugs. A guide to the basics of modeling and simulation programs, Biopharmaceutics Modeling and Simulations offers pharmaceutical scientists the keys to understanding how they work and are applied in creating drugs with desired medicinal properties. Beginning with a focus on the oral absorption of drugs, the book discusses: The central dogma of oral drug absorption (the interplay of dissolution, solubility, and permeability of a drug), which forms the basis of the biopharmaceutical classification system (BCS) The concept of drug concentration How to simulate key drug absorption processes The physiological and drug property data used for biopharmaceutical modeling Reliable practices for reporting results With over 200 figures and illustrations and a peerless examination of all the key aspects of drug research—including running and interpreting models, validation, and compound and formulation selection—this reference seamlessly brings together the proven practical approaches essential to developing the safe and effective medicines of tomorrow.

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Sheila Peters Annie Physiologically-Based Pharmacokinetic (PBPK) Modeling and Simulations. Principles, Methods, and Applications in the Pharmaceutical Industry

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Артикул:

31230465

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The only book dedicated to physiologically-based pharmacokinetic modeling in pharmaceutical science Physiologically-based pharmacokinetic (PBPK) modeling has become increasingly widespread within the pharmaceutical industry over the last decade, but without one dedicated book that provides the information researchers need to learn these new techniques, its applications are severely limited. Describing the principles, methods, and applications of PBPK modeling as used in pharmaceutics, Physiologically-Based Pharmacokinetic (PBPK) Modeling and Simulations fills this void. Connecting theory with practice, the book explores the incredible potential of PBPK modeling for improving drug discovery and development. Comprised of two parts, the book first provides a detailed and systematic treatment of the principles behind physiological modeling of pharmacokinetic processes, inter-individual variability, and drug interactions for small molecule drugs and biologics. The second part looks in greater detail at the powerful applications of PBPK to drug research. Designed for a wide audience encompassing readers looking for a brief overview of the field as well as those who need more detail, the book includes a range of important learning aids. Featuring end-of-chapter keywords for easy reference—a valuable asset for general or novice readers without a PBPK background—along with an extensive bibliography for those looking for further information, Physiologically- Based Pharmacokinetic (PBPK) Modeling and Simulations is the essential single-volume text on one of the hottest topics in the pharmaceutical sciences today.

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Группа авторов Mathematical Modeling with Multidisciplinary Applications

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Артикул:

34407432

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Features mathematical modeling techniques and real-world processes with applications in diverse fields Mathematical Modeling with Multidisciplinary Applications details the interdisciplinary nature of mathematical modeling and numerical algorithms. The book combines a variety of applications from diverse fields to illustrate how the methods can be used to model physical processes, design new products, find solutions to challenging problems, and increase competitiveness in international markets. Written by leading scholars and international experts in the field, the book presents new and emerging topics in areas including finance and economics, theoretical and applied mathematics, engineering and machine learning, physics, chemistry, ecology, and social science. In addition, the book thoroughly summarizes widely used mathematical and numerical methods in mathematical modeling and features: Diverse topics such as partial differential equations (PDEs), fractional calculus, inverse problems by ordinary differential equations (ODEs), semigroups, decision theory, risk analysis, Bayesian estimation, nonlinear PDEs in financial engineering, perturbation analysis, and dynamic system modeling Case studies and real-world applications that are widely used for current mathematical modeling courses, such as the green house effect and Stokes flow estimation Comprehensive coverage of a wide range of contemporary topics, such as game theory, statistical models, and analytical solutions to numerical methods Examples, exercises with select solutions, and detailed references to the latest literature to solidify comprehensive learning New techniques and applications with balanced coverage of PDEs, discrete models, statistics, fractional calculus, and more Mathematical Modeling with Multidisciplinary Applications is an excellent book for courses on mathematical modeling and applied mathematics at the upper-undergraduate and graduate levels. The book also serves as a valuable reference for research scientists, mathematicians, and engineers who would like to develop further insights into essential mathematical tools.

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Michael J. Panik Growth Curve Modeling

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Артикул:

34410776

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Features recent trends and advances in the theory and techniques used to accurately measure and model growth Growth Curve Modeling: Theory and Applications features an accessible introduction to growth curve modeling and addresses how to monitor the change in variables over time since there is no “one size fits all” approach to growth measurement. A review of the requisite mathematics for growth modeling and the statistical techniques needed for estimating growth models are provided, and an overview of popular growth curves, such as linear, logarithmic, reciprocal, logistic, Gompertz, Weibull, negative exponential, and log-logistic, among others, is included. In addition, the book discusses key application areas including economic, plant, population, forest, and firm growth and is suitable as a resource for assessing recent growth modeling trends in the medical field. SAS® is utilized throughout to analyze and model growth curves, aiding readers in estimating specialized growth rates and curves. Including derivations of virtually all of the major growth curves and models, Growth Curve Modeling: Theory and Applications also features: • Statistical distribution analysis as it pertains to growth modeling • Trend estimations • Dynamic site equations obtained from growth models • Nonlinear regression • Yield-density curves • Nonlinear mixed effects models for repeated measurements data Growth Curve Modeling: Theory and Applications is an excellent resource for statisticians, public health analysts, biologists, botanists, economists, and demographers who require a modern review of statistical methods for modeling growth curves and analyzing longitudinal data. The book is also useful for upper-undergraduate and graduate courses on growth modeling.

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